Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels
Nature neuroscience, 2022•nature.com
It remains unclear how immune cells from skull bone marrow niches are recruited to the
meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via
dura–skull channels, and CSF proteins signal onto diverse cell types within the niches. After
spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into
meninges. This reveals a mechanism of CNS-to-bone-marrow communication via CSF that
regulates CNS immune responses.
meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via
dura–skull channels, and CSF proteins signal onto diverse cell types within the niches. After
spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into
meninges. This reveals a mechanism of CNS-to-bone-marrow communication via CSF that
regulates CNS immune responses.
Abstract
It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura–skull channels, and CSF proteins signal onto diverse cell types within the niches. After spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into meninges. This reveals a mechanism of CNS-to-bone-marrow communication via CSF that regulates CNS immune responses.
nature.com
