Familial segregation of hemangiomas and vascular malformations as an autosomal dominant trait
F Blei, J Walter, SJ Orlow, DA Marchuk - Archives of dermatology, 1998 - jamanetwork.com
Background The pathogenesis of infantile hemangiomas is not yet understood. Growth
factors and hormonal and mechanical influences have been thought to affect the focal
abnormal growth of endothelial cells in these lesions. However, these influences may
represent secondary responses to an underlying primary molecular event leading to the
development of hemangiomas. Observations We report the rare familial occurrence of
hemangiomas and/or vascular malformations in 6 kindreds, suggesting autosomal dominant …
factors and hormonal and mechanical influences have been thought to affect the focal
abnormal growth of endothelial cells in these lesions. However, these influences may
represent secondary responses to an underlying primary molecular event leading to the
development of hemangiomas. Observations We report the rare familial occurrence of
hemangiomas and/or vascular malformations in 6 kindreds, suggesting autosomal dominant …
