Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ–focal adhesion kinase signaling circuitry
G proteins and G protein–coupled receptors activate a diverse array of signal transduction
pathways that promote cell growth and survival. Indeed, hot spot–activating mutations in
GNAQ/GNA11, encoding Gαq proteins, are known to be driver oncogenes in uveal
melanoma (UM), for which there are limited effective therapies currently available. Focal
adhesion kinase (FAK) has been recently shown to be a central mediator of Gαq-driven
signaling in UM, and as a result, is being explored clinically as a therapeutic target for UM …
pathways that promote cell growth and survival. Indeed, hot spot–activating mutations in
GNAQ/GNA11, encoding Gαq proteins, are known to be driver oncogenes in uveal
melanoma (UM), for which there are limited effective therapies currently available. Focal
adhesion kinase (FAK) has been recently shown to be a central mediator of Gαq-driven
signaling in UM, and as a result, is being explored clinically as a therapeutic target for UM …
