Papillary hemangioma (PH) is a small, primarily dermal lesion occurring predominantly in
the head and neck in both children and adults. Its signature characteristics are dilated thin-
walled channels containing papillary clusters of mainly capillary-sized vessels and
endothelial cytoplasmic eosinophilic inclusions. Given certain histopathologic similarities to
congenital hemangioma which harbor mutations in GNAQ and GNA11, we investigated
whether similar mutations are present in PH. Seven PH specimens were studied. All …