A common thread through malignant and nonmalignant diseases alerts us to a therapeutic
opportunity to seize: disease may originate from genetic mutations, but resulting
maladaptive/unhealthy cell fates and functions are mediated by epigenetic enzymes, that
are druggable. Epigenetic enzymes modify DNA, and/or the histones around which DNA is
organized, to regulate access to genes by the basal transcription factor machinery that
transcribes genes. Epigenetic enzymes can be divided usefully into those that facilitate gene …