A native soluble form of CTLA-4
MK Oaks, KM Hallett, RT Penwell, EC Stauber… - Cellular …, 2000 - Elsevier
CTLA-4 is an immunoregulatory receptor expressed on the surface of activated T and B
lymphocytes. The counterreceptors for CTLA-4 are the B7 family molecules. We describe
alternatively spliced mRNAs expressed in hematolymphoid tissues of humans, mice, and
rats that lack the transmembrane domain coded by exon 3 of the CTLA-4 gene. These
alternate transcripts were detected by RT-PCR in B cells and resting T cells of both the CD4
and the CD8 phenotype. Activation of human blood mononuclear cells with PHA or anti …
lymphocytes. The counterreceptors for CTLA-4 are the B7 family molecules. We describe
alternatively spliced mRNAs expressed in hematolymphoid tissues of humans, mice, and
rats that lack the transmembrane domain coded by exon 3 of the CTLA-4 gene. These
alternate transcripts were detected by RT-PCR in B cells and resting T cells of both the CD4
and the CD8 phenotype. Activation of human blood mononuclear cells with PHA or anti …
