CD19-targeting CAR T cells for myositis and interstitial lung disease associated with antisynthetase syndrome
AC Pecher, L Hensen, R Klein, R Schairer, K Lutz… - Jama, 2023 - jamanetwork.com
Importance Autoimmune disorders can affect various organs and if refractory, can be life
threatening. Recently, CD19-targeting–chimeric antigen receptor (CAR) T cells were
efficacious as an immune suppressive agent in 6 patients with refractory systemic lupus
erythematosus and in 1 patient with antisynthetase syndrome. Objective To test the safety
and efficacy of CD19-targeting CAR T cells in a patient with severe antisynthetase
syndrome, a complex autoimmune disorder with evidence for B-and T-cell involvement …
threatening. Recently, CD19-targeting–chimeric antigen receptor (CAR) T cells were
efficacious as an immune suppressive agent in 6 patients with refractory systemic lupus
erythematosus and in 1 patient with antisynthetase syndrome. Objective To test the safety
and efficacy of CD19-targeting CAR T cells in a patient with severe antisynthetase
syndrome, a complex autoimmune disorder with evidence for B-and T-cell involvement …
