Low antigen-specific CD4 T-cell immune responses despite normal absolute CD4 counts after long-term antiretroviral therapy an African cohort
R Nabatanzi, L Bayigga, I Ssinabulya, A Kiragga… - Immunology letters, 2014 - Elsevier
Background CD4 counts guide antiretroviral therapy (ART) initiation and prophylaxis for
opportunistic infections. It is unclear whether normal CD4 counts translate to normalized
immune responses among ART-treated adults. We compared antigen-specific CD4 T-cell
immune responses among ART-treated adults with CD4≥ 500 cells/μl, optimal immune
responders (O-IR), and their age-matched healthy HIV-negative counterparts. Methods In a
sample-based case–control study, cryopreserved peripheral blood mononuclear cells from …
opportunistic infections. It is unclear whether normal CD4 counts translate to normalized
immune responses among ART-treated adults. We compared antigen-specific CD4 T-cell
immune responses among ART-treated adults with CD4≥ 500 cells/μl, optimal immune
responders (O-IR), and their age-matched healthy HIV-negative counterparts. Methods In a
sample-based case–control study, cryopreserved peripheral blood mononuclear cells from …