Transcriptome analysis of rat dorsal hippocampal CA1 after an early life seizure induced by kainic acid
H O'Leary, L Vanderlinden, L Southard, A Castano… - Epilepsy research, 2020 - Elsevier
Seizures that occur during early development are associated with adverse
neurodevelopmental outcomes. Causation and mechanisms are currently under
investigation. Induction of an early life seizure by kainic acid (KA) in immature rats on post-
natal day (P) 7 results in behavioral changes in the adult rat that reflect social and
intellectual deficits without overt cellular damage. Our previous work also demonstrated
increased expression of CA1 hippocampal long-term potentiation (LTP) and reduced …
neurodevelopmental outcomes. Causation and mechanisms are currently under
investigation. Induction of an early life seizure by kainic acid (KA) in immature rats on post-
natal day (P) 7 results in behavioral changes in the adult rat that reflect social and
intellectual deficits without overt cellular damage. Our previous work also demonstrated
increased expression of CA1 hippocampal long-term potentiation (LTP) and reduced …