[HTML][HTML] Maturation-dependent behavioral deficits and cell injury in developing animals during the subacute postictal period
LM Mlsna, S Koh - Epilepsy & Behavior, 2013 - Elsevier
Prolonged early-life seizures are associated with disruptions of affective and cognitive
function. Postictal disturbances, temporary functional deficits that persist for hours to days
after seizures, have not yet been thoroughly characterized. Here, we used kainic acid (KA) to
induce status epilepticus (SE) in immature rats at three developmental stages (postnatal day
(P) 15, 21, or 30) and subsequently assessed spatial learning and memory in a Barnes
maze, exploratory behavior in an open field, and the spatiotemporal distribution of cell injury …
function. Postictal disturbances, temporary functional deficits that persist for hours to days
after seizures, have not yet been thoroughly characterized. Here, we used kainic acid (KA) to
induce status epilepticus (SE) in immature rats at three developmental stages (postnatal day
(P) 15, 21, or 30) and subsequently assessed spatial learning and memory in a Barnes
maze, exploratory behavior in an open field, and the spatiotemporal distribution of cell injury …