Early-life seizures alter synaptic calcium-permeable AMPA receptor function and plasticity
JJ Lippman-Bell, C Zhou, H Sun, JS Feske… - Molecular and Cellular …, 2016 - Elsevier
Abstract Calcium (Ca 2+)-mediated 4 signaling pathways are critical to synaptic plasticity. In
adults, the NMDA glutamate receptor (NMDAR) represents a major route for activity-
dependent synaptic Ca 2+ entry. However, during neonatal development, when synaptic
plasticity is particularly high, many AMPA glutamate receptors (AMPARs) are also
permeable to Ca 2+(CP-AMPAR) due to low GluA2 subunit expression, providing an
additional route for activity-and glutamate-dependent Ca 2+ influx and subsequent …
adults, the NMDA glutamate receptor (NMDAR) represents a major route for activity-
dependent synaptic Ca 2+ entry. However, during neonatal development, when synaptic
plasticity is particularly high, many AMPA glutamate receptors (AMPARs) are also
permeable to Ca 2+(CP-AMPAR) due to low GluA2 subunit expression, providing an
additional route for activity-and glutamate-dependent Ca 2+ influx and subsequent …