Establishment and large-scale expansion of minimally cultured “young” tumor infiltrating lymphocytes for adoptive transfer therapy
O Itzhaki, E Hovav, Y Ziporen, D Levy… - Journal of …, 2011 - journals.lww.com
Abstract Treatment of metastatic melanoma patients with adoptively transferred tumor
infiltrating lymphocytes (TIL) has developed into an effective therapy. Various studies
reported objective responses of 50% and more. The use of unselected, minimally cultured,
bulk TIL (Young-TIL) has simplified the TIL production process and may therefore, allow the
accessibility of this approach to cancer centers worldwide. This article describes the precise
process leading to the large-scale production of Young-TIL for therapy. We have enrolled 55 …
infiltrating lymphocytes (TIL) has developed into an effective therapy. Various studies
reported objective responses of 50% and more. The use of unselected, minimally cultured,
bulk TIL (Young-TIL) has simplified the TIL production process and may therefore, allow the
accessibility of this approach to cancer centers worldwide. This article describes the precise
process leading to the large-scale production of Young-TIL for therapy. We have enrolled 55 …
