The requirement of more than one antigenic determinant for immunogenicity
K Rajewsky, V Schirrmacher, S Nase… - The Journal of …, 1969 - rupress.org
K Rajewsky, V Schirrmacher, S Nase, NK Jerne
The Journal of Experimental Medicine, 1969•rupress.orgRabbits primarily stimulated with a BSA (bovine serum albumin)-sulfanilic acid complex will
produce a good secondary response to the sulfanilic acid hapten if the carrier used in the
secondary stimulus is again BSA, and not if the secondary carrier is HGG (human gamma
globulin). In the latter situation, a good secondary response is obtained, however, if the
rabbits are pretreated a few weeks earlier with free HGG. We conclude that the immune
stimulus involves the recognition of carrier determinants unrelated to the hapten. As the …
produce a good secondary response to the sulfanilic acid hapten if the carrier used in the
secondary stimulus is again BSA, and not if the secondary carrier is HGG (human gamma
globulin). In the latter situation, a good secondary response is obtained, however, if the
rabbits are pretreated a few weeks earlier with free HGG. We conclude that the immune
stimulus involves the recognition of carrier determinants unrelated to the hapten. As the …
Rabbits primarily stimulated with a BSA (bovine serum albumin)-sulfanilic acid complex will produce a good secondary response to the sulfanilic acid hapten if the carrier used in the secondary stimulus is again BSA, and not if the secondary carrier is HGG (human gamma globulin). In the latter situation, a good secondary response is obtained, however, if the rabbits are pretreated a few weeks earlier with free HGG. We conclude that the immune stimulus involves the recognition of carrier determinants unrelated to the hapten.
As the receptors for recognition of unrelated determinants are probably situated on different cells, we suggest that the immune stimulus leading to antibody formation requires the interaction of two antigen-bridged cells.
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