[HTML][HTML] Sustained protective immunity against Bordetella pertussis nasal colonization by intranasal immunization with a vaccine-adjuvant combination that induces IL …
Current acellular pertussis (aP) vaccines induce strong antibody and Th2 responses but fail
to protect against nasal colonization and transmission of Bordetella pertussis. Furthermore,
immunity wanes rapidly after immunization. We have developed a novel adjuvant
combination (called LP-GMP), comprising c-di-GMP, an intracellular receptor stimulator of
interferon genes (STING) agonist, and LP1569, a TLR2 agonist from B. pertussis, which
synergistically induces production of IFN-β, IL-12 and IL-23, and maturation of dendritic …
to protect against nasal colonization and transmission of Bordetella pertussis. Furthermore,
immunity wanes rapidly after immunization. We have developed a novel adjuvant
combination (called LP-GMP), comprising c-di-GMP, an intracellular receptor stimulator of
interferon genes (STING) agonist, and LP1569, a TLR2 agonist from B. pertussis, which
synergistically induces production of IFN-β, IL-12 and IL-23, and maturation of dendritic …