Antibodies to hepatitis B surface antigen potentiate the response of human T lymphocyte clones to the same antigen
E Celis, TW Chang - Science, 1984 - science.org
E Celis, TW Chang
Science, 1984•science.orgHuman T-helper lymphocyte clones specific for hepatitis B virus surface antigen (HBsAg)
proliferate on stimulation with HBsAg in vitro. Antibodies specific for HBsAg, but no other
antibodies, augment this proliferative response. In the presence of antibodies to HBsAg, the
maximum response could be achieved at HBsAg concentrations that were 1 percent of those
required in the absence of the antibodies. These findings suggest that antigen-specific
antibodies exert regulatory controls on T cells that recognize the same antigens.
proliferate on stimulation with HBsAg in vitro. Antibodies specific for HBsAg, but no other
antibodies, augment this proliferative response. In the presence of antibodies to HBsAg, the
maximum response could be achieved at HBsAg concentrations that were 1 percent of those
required in the absence of the antibodies. These findings suggest that antigen-specific
antibodies exert regulatory controls on T cells that recognize the same antigens.
Human T-helper lymphocyte clones specific for hepatitis B virus surface antigen (HBsAg) proliferate on stimulation with HBsAg in vitro. Antibodies specific for HBsAg, but no other antibodies, augment this proliferative response. In the presence of antibodies to HBsAg, the maximum response could be achieved at HBsAg concentrations that were 1 percent of those required in the absence of the antibodies. These findings suggest that antigen-specific antibodies exert regulatory controls on T cells that recognize the same antigens.
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