Delivery of antigen to nasal-associated lymphoid tissue microfold cells through secretory IgA targeting local dendritic cells confers protective immunity
N Rochereau, V Pavot, B Verrier, F Jospin… - Journal of Allergy and …, 2016 - Elsevier
Background Transmission of mucosal pathogens relies on their ability to bind to the surfaces
of epithelial cells, to cross this thin barrier, and to gain access to target cells and tissues,
leading to systemic infection. This implies that pathogen-specific immunity at mucosal sites
is critical for the control of infectious agents using these routes to enter the body. Although
mucosal delivery would ensure the best onset of protective immunity, most of the candidate
vaccines are administered through the parenteral route. Objective The present study …
of epithelial cells, to cross this thin barrier, and to gain access to target cells and tissues,
leading to systemic infection. This implies that pathogen-specific immunity at mucosal sites
is critical for the control of infectious agents using these routes to enter the body. Although
mucosal delivery would ensure the best onset of protective immunity, most of the candidate
vaccines are administered through the parenteral route. Objective The present study …