Transcriptional regulation of the uncoupling protein-1 gene
Regulated transcription of the uncoupling protein-1 (UCP1) gene, and subsequent UCP1
protein synthesis, is a hallmark of the acquisition of the differentiated, thermogenically
competent status of brown and beige/brite adipocytes, as well as of the responsiveness of
brown and beige/brite adipocytes to adaptive regulation of thermogenic activity. The 5′ non-
coding region of the UCP1 gene contains regulatory elements that confer tissue specificity,
differentiation dependence, and neuro-hormonal regulation to UCP1 gene transcription …
protein synthesis, is a hallmark of the acquisition of the differentiated, thermogenically
competent status of brown and beige/brite adipocytes, as well as of the responsiveness of
brown and beige/brite adipocytes to adaptive regulation of thermogenic activity. The 5′ non-
coding region of the UCP1 gene contains regulatory elements that confer tissue specificity,
differentiation dependence, and neuro-hormonal regulation to UCP1 gene transcription …
