[HTML][HTML] Specificity and rate of human and mouse liver and plasma phosphatidylcholine synthesis analyzed in vivo [S]
CJ Pynn, NG Henderson, H Clark, G Koster… - Journal of lipid …, 2011 - ASBMB
Phosphatidylcholine (PC) synthesis by the direct cytidine diphosphate choline (CDP-
choline) pathway in rat liver generates predominantly mono-and di-unsaturated molecular
species, while polyunsaturated PC species are synthesized largely by the
phosphatidylethanolamine-N-methyltransferase (PEMT) pathway. Although altered PC
synthesis has been suggested to contribute to development of hepatocarcinoma and
nonalcoholic steatohepatitis, analysis of the specificity of hepatic PC metabolism in human …
choline) pathway in rat liver generates predominantly mono-and di-unsaturated molecular
species, while polyunsaturated PC species are synthesized largely by the
phosphatidylethanolamine-N-methyltransferase (PEMT) pathway. Although altered PC
synthesis has been suggested to contribute to development of hepatocarcinoma and
nonalcoholic steatohepatitis, analysis of the specificity of hepatic PC metabolism in human …