[HTML][HTML] Structural Insights into the Transport Mechanism of the Human Sodium-dependent Lysophosphatidylcholine Transporter MFSD2A*♦
Major facilitator superfamily domain containing 2A (MFSD2A) was recently characterized as
a sodium-dependent lysophosphatidylcholine transporter expressed at the blood-brain
barrier endothelium. It is the primary route for importation of docosohexaenoic acid and
other long-chain fatty acids into fetal and adult brain and is essential for mouse and human
brain growth and function. Remarkably, MFSD2A is the first identified major facilitator
superfamily member that uniquely transports lipids, implying that MFSD2A harbors unique …
a sodium-dependent lysophosphatidylcholine transporter expressed at the blood-brain
barrier endothelium. It is the primary route for importation of docosohexaenoic acid and
other long-chain fatty acids into fetal and adult brain and is essential for mouse and human
brain growth and function. Remarkably, MFSD2A is the first identified major facilitator
superfamily member that uniquely transports lipids, implying that MFSD2A harbors unique …