[HTML][HTML] Mfsd2a is a transporter for the essential ω-3 fatty acid docosahexaenoic acid (DHA) in eye and is important for photoreceptor cell development
BH Wong, JP Chan, A Cazenave-Gassiot… - Journal of Biological …, 2016 - ASBMB
Eye photoreceptor membrane discs in outer rod segments are highly enriched in the visual
pigment rhodopsin and the ω-3 fatty acid docosahexaenoic acid (DHA). The eye acquires
DHA from blood, but transporters for DHA uptake across the blood-retinal barrier or retinal
pigment epithelium have not been identified. Mfsd2a is a newly described sodium-
dependent lysophosphatidylcholine (LPC) symporter expressed at the blood-brain barrier
that transports LPCs containing DHA and other long-chain fatty acids. LPC transport via …
pigment rhodopsin and the ω-3 fatty acid docosahexaenoic acid (DHA). The eye acquires
DHA from blood, but transporters for DHA uptake across the blood-retinal barrier or retinal
pigment epithelium have not been identified. Mfsd2a is a newly described sodium-
dependent lysophosphatidylcholine (LPC) symporter expressed at the blood-brain barrier
that transports LPCs containing DHA and other long-chain fatty acids. LPC transport via …