[HTML][HTML] Molecular distinction of phosphatidylcholine synthesis between the CDP-choline pathway and phosphatidylethanolamine methylation pathway
CJ DeLong, YJ Shen, MJ Thomas, Z Cui - Journal of Biological Chemistry, 1999 - ASBMB
In addition to the CDP-choline pathway for phosphatidylcholine (PC) synthesis, the liver has
a unique phosphatidylethanolamine (PE) methyltransferase activity for PC synthesis via
three methylations of the ethanolamine moiety of PE. Previous studies indicate that the two
pathways are functionally different and not interchangeable even though PC is the common
product of both pathways. This study was designed to test the hypothesis that these two
pathways produce different profiles of PC species. The PC species from these two pathways …
a unique phosphatidylethanolamine (PE) methyltransferase activity for PC synthesis via
three methylations of the ethanolamine moiety of PE. Previous studies indicate that the two
pathways are functionally different and not interchangeable even though PC is the common
product of both pathways. This study was designed to test the hypothesis that these two
pathways produce different profiles of PC species. The PC species from these two pathways …