Cure of an established nonimmunogenic tumor, SCC VII, with a novel interleukin 12–based immunotherapy regimen in C3H mice
AH Mandpe, K Tsung, JA Norton - Archives of Otolaryngology …, 2003 - jamanetwork.com
Objective To develop a murine model of effective treatment with immunotherapy for
established head and neck squamous cell carcinoma. Design Prospective animal study.
Subjects Female C3H mice, 8 to 12 weeks old. Interventions A subcutaneous inoculation of
2× 10 5 SCC VII cells in C3H mice was established for 7 to 12 days. Tests for concomitant
immunity were performed, with and without interleukin 12 modification. Tumors were also
tested for responsiveness to interleukin 12 (5 mice) and to cyclophosphamide followed by …
established head and neck squamous cell carcinoma. Design Prospective animal study.
Subjects Female C3H mice, 8 to 12 weeks old. Interventions A subcutaneous inoculation of
2× 10 5 SCC VII cells in C3H mice was established for 7 to 12 days. Tests for concomitant
immunity were performed, with and without interleukin 12 modification. Tumors were also
tested for responsiveness to interleukin 12 (5 mice) and to cyclophosphamide followed by …