IFN-β-regulated genes show abnormal expression in therapy-naïve relapsing–remitting MS mononuclear cells: Gene expression analysis employing all reported …
KD Yamaguchi, DL Ruderman, E Croze… - Journal of …, 2008 - Elsevier
The molecular mechanism by which interferon beta (IFN-β) is effective in treating multiple
sclerosis is not well understood. Mononuclear cells from therapy-naïve MS patients, IFN-β-
1b-treated MS patients, and healthy controls were analyzed to examine mRNA changes that
characterize both the disease and its treatment. The scientific literature was
comprehensively searched for all protein–protein interactions. In MS patients who had never
been treated with IFN-β, statistical analysis revealed coordinate changes in mRNA …
sclerosis is not well understood. Mononuclear cells from therapy-naïve MS patients, IFN-β-
1b-treated MS patients, and healthy controls were analyzed to examine mRNA changes that
characterize both the disease and its treatment. The scientific literature was
comprehensively searched for all protein–protein interactions. In MS patients who had never
been treated with IFN-β, statistical analysis revealed coordinate changes in mRNA …