[HTML][HTML] Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis factor-α
A key function of activated macrophages is to secrete proinflammatory cytokines such as
TNFα; however, the intracellular pathway and machinery responsible for cytokine trafficking
and secretion is largely undefined. Here we show that individual SNARE proteins involved
in vesicle docking and fusion are regulated at both gene and protein expression upon
stimulation with the bacterial cell wall component lipopolysaccharide. Focusing on two
intracellular SNARE proteins, Vti1b and syntaxin 6 (Stx6), we show that they are up …
TNFα; however, the intracellular pathway and machinery responsible for cytokine trafficking
and secretion is largely undefined. Here we show that individual SNARE proteins involved
in vesicle docking and fusion are regulated at both gene and protein expression upon
stimulation with the bacterial cell wall component lipopolysaccharide. Focusing on two
intracellular SNARE proteins, Vti1b and syntaxin 6 (Stx6), we show that they are up …