Microenvironmental interactions in chronic lymphocytic leukemia: the master role of CD49d
M Dal Bo, E Tissino, D Benedetti, C Caldana… - Seminars in …, 2014 - Elsevier
Chronic lymphocytic leukemia (CLL) is a clinically heterogeneous disease characterized by
the accumulation/expansion of a clonal population of neoplastic cells with the morphologic
appearance of small mature B lymphocytes in blood, bone marrow, and lymphoid organs. A
combination of genetic lesions is primarily responsible for the first step (s) of neoplastic
transformation, along with microenvironmental signals, which concurrently operate by
enhancing proliferation and/or inhibiting apoptosis. In this context, CD49d is known to play a …
the accumulation/expansion of a clonal population of neoplastic cells with the morphologic
appearance of small mature B lymphocytes in blood, bone marrow, and lymphoid organs. A
combination of genetic lesions is primarily responsible for the first step (s) of neoplastic
transformation, along with microenvironmental signals, which concurrently operate by
enhancing proliferation and/or inhibiting apoptosis. In this context, CD49d is known to play a …
