Depressed interferon gamma production and monocyte HLA-DR expression after severe injury
DH Livingston, SH Appel, SR Wellhausen… - Archives of …, 1988 - jamanetwork.com
• Monocyte HLA-DR antigen expression and mitogen-stimulated interferon gamma
production were measured sequentially on days 1, 3, 7, 14, and 21 after admission in 20
multiply injured patients (mean Injury Severity Score, 33). Ten patients recovered
uneventfully and ten developed a major infection, three of whom died. Trauma resulted in
immediate and profound depression of both interferon gamma production and monocyte
HLA-DR antigen expression compared with controls. Interferon gamma remained below …
production were measured sequentially on days 1, 3, 7, 14, and 21 after admission in 20
multiply injured patients (mean Injury Severity Score, 33). Ten patients recovered
uneventfully and ten developed a major infection, three of whom died. Trauma resulted in
immediate and profound depression of both interferon gamma production and monocyte
HLA-DR antigen expression compared with controls. Interferon gamma remained below …
