[HTML][HTML] Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells
S Yalcin, X Zhang, JP Luciano, SK Mungamuri… - Journal of Biological …, 2008 - ASBMB
Unchecked accumulation of reactive oxygen species (ROS) compromises maintenance of
hematopoietic stem cells. Regulation of ROS by the tumor suppressor protein ataxia
telangiectasia mutated (ATM) is critical for preserving the hematopoietic stem cell pool. In
this study we demonstrate that the Foxo3 member of the Forkhead Box O (FoxO) family of
transcription factors is essential for normal ATM expression. In addition, we show that loss of
Foxo3 leads to defects in hematopoietic stem cells, and these defects result from an …
hematopoietic stem cells. Regulation of ROS by the tumor suppressor protein ataxia
telangiectasia mutated (ATM) is critical for preserving the hematopoietic stem cell pool. In
this study we demonstrate that the Foxo3 member of the Forkhead Box O (FoxO) family of
transcription factors is essential for normal ATM expression. In addition, we show that loss of
Foxo3 leads to defects in hematopoietic stem cells, and these defects result from an …