[HTML][HTML] Processing of the transforming growth factor β type I and II receptors: biosynthesis and ligand-induced regulation
KM Koli, CL Arteaga - Journal of Biological Chemistry, 1997 - ASBMB
Three cell surface transforming growth factor β (TGFβ) receptor (R) proteins regulate the
effects of TGFβ isoforms on growth and differentiation. TGFβ-IR and-IIR are transmembrane
serine/threonine kinases directly mediating the signaling across the plasma membrane.
Both TGFβ and its receptors are ubiquitously expressed, hence the fine regulation of the
multiplicity of responses most likely involves several levels of control including the regulation
of expression, complex formation, and down-regulation of the receptor proteins. In mink lung …
effects of TGFβ isoforms on growth and differentiation. TGFβ-IR and-IIR are transmembrane
serine/threonine kinases directly mediating the signaling across the plasma membrane.
Both TGFβ and its receptors are ubiquitously expressed, hence the fine regulation of the
multiplicity of responses most likely involves several levels of control including the regulation
of expression, complex formation, and down-regulation of the receptor proteins. In mink lung …