KSHV sequences in biopsies and cultured spindle cells of epidemic, iatrogenic and Mediterranean forms of Kaposi's sarcoma
The pathogenesis of Kaposi's sarcoma (KS) is still unclear, and several factors appear to be
involved in the onset of the Kaposi's lesion. Epidemiological studies suggest that a common
infective agent may contribute to KS. Sequences which appear to represent a new
gammaherpesvirus, currently termed KSHV/HHV8, have recently been identified in KS. To
further examine the relationship between this virus and KS, we obtained biopsy samples of
KS lesions; these samples, the spindle cells cultured from these lesions and the PBMC of …
involved in the onset of the Kaposi's lesion. Epidemiological studies suggest that a common
infective agent may contribute to KS. Sequences which appear to represent a new
gammaherpesvirus, currently termed KSHV/HHV8, have recently been identified in KS. To
further examine the relationship between this virus and KS, we obtained biopsy samples of
KS lesions; these samples, the spindle cells cultured from these lesions and the PBMC of …