[HTML][HTML] Inflammatory cytokines induce production of CHI3L1 by articular chondrocytes
AD Recklies, H Ling, C White, SM Bernier - Journal of Biological Chemistry, 2005 - ASBMB
Elevated levels of CHI3L1 (chitinase-3-like protein 1) are associated with disorders
exhibiting increased connective tissue turnover, such as rheumatoid arthritis, osteoarthritis,
scleroderma, and cirrhosis of the liver. This secreted protein is not synthesized in young
healthy cartilage, but is produced in cartilage from old donors or patients with osteoarthritis.
The molecular processes governing the induction of CHI3L1 are currently unknown. To
elucidate the molecular events involved in CHI3L1 synthesis, we investigated two models of …
exhibiting increased connective tissue turnover, such as rheumatoid arthritis, osteoarthritis,
scleroderma, and cirrhosis of the liver. This secreted protein is not synthesized in young
healthy cartilage, but is produced in cartilage from old donors or patients with osteoarthritis.
The molecular processes governing the induction of CHI3L1 are currently unknown. To
elucidate the molecular events involved in CHI3L1 synthesis, we investigated two models of …