Influence of antiretroviral therapy on programmed death-1 (CD279) expression on T cells in lymph nodes of human immunodeficiency virus–infected individuals
S Ehrhard, M Wernli, U Dürmüller, M Battegay, F Gudat… - Human pathology, 2009 - Elsevier
Human immunodeficiency virus infection leads to T-cell exhaustion and involution of
lymphoid tissue. Recently, the programmed death-1 pathway was found to be crucial for
virus-specific T-cell exhaustion during human immunodeficiency virus infection.
Programmed death-1 expression was elevated on human immunodeficiency virus–specific
peripheral blood CD8+ and CD4+ T cells and correlated with disease severity. During
human immunodeficiency infection, lymphoid tissue acts as a major viral reservoir and is an …
lymphoid tissue. Recently, the programmed death-1 pathway was found to be crucial for
virus-specific T-cell exhaustion during human immunodeficiency virus infection.
Programmed death-1 expression was elevated on human immunodeficiency virus–specific
peripheral blood CD8+ and CD4+ T cells and correlated with disease severity. During
human immunodeficiency infection, lymphoid tissue acts as a major viral reservoir and is an …