[HTML][HTML] Activation of the B-cell Surface Receptor CD40 Induces A20, a Novel Zinc Finger Protein That Inhibits Apoptosis (∗)
V Sarma, Z Lin, L Clark, BM Rust, M Tewari… - Journal of Biological …, 1995 - ASBMB
CD40 activation is critical for B-cell function, leading to activation and expression of cell
surface markers, proliferation, immunoglobulin class switching and inhibition of programmed
cell death (PCD). Germinal center B-cells, for example, can be prevented from undergoing
PCD by CD40 activation. The mechanism by which PCD is inhibited has been an enigma. A
potential role for A20, a novel zinc finger protein, in inhibiting B-cell apoptosis was
suggested by our previous finding that it is induced by the Epstein-Barr virus LMP-1 gene …
surface markers, proliferation, immunoglobulin class switching and inhibition of programmed
cell death (PCD). Germinal center B-cells, for example, can be prevented from undergoing
PCD by CD40 activation. The mechanism by which PCD is inhibited has been an enigma. A
potential role for A20, a novel zinc finger protein, in inhibiting B-cell apoptosis was
suggested by our previous finding that it is induced by the Epstein-Barr virus LMP-1 gene …