Toll-like receptor-7 modulates immune complex glomerulonephritis
Viral infections may trigger immune complex glomerulonephritis via Toll-like receptors
(TLR), as certain TLR trigger immunity upon recognition of viral nucleic acids. On the basis
of previous findings regarding viral double-stranded RNA and TLR3 in experimental lupus
erythematosus, a similar role for TLR7 that recognizes viral single-stranded RNA was
hypothesized. Immunostaining of kidney sections of nephritic MRL lpr/lpr mice revealed
TLR7 expression in infiltrating ER-HR3–positive macrophages and few CD11c-positive …
(TLR), as certain TLR trigger immunity upon recognition of viral nucleic acids. On the basis
of previous findings regarding viral double-stranded RNA and TLR3 in experimental lupus
erythematosus, a similar role for TLR7 that recognizes viral single-stranded RNA was
hypothesized. Immunostaining of kidney sections of nephritic MRL lpr/lpr mice revealed
TLR7 expression in infiltrating ER-HR3–positive macrophages and few CD11c-positive …