[HTML][HTML] Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function
K Watanabe, T Ozaki, T Nakagawa, K Miyazaki… - Journal of Biological …, 2002 - ASBMB
p73 shares high sequence homology with the tumor suppressor p53. Like p53, ectopic
overexpression of p73 induces cell cycle arrest and/or apoptosis, and these biological
activities are linked to its sequence-specific transactivation function. The COOH-terminal
region of p73 is unique and has a function to modulate DNA-binding ability and
transactivation activity. To identify and characterize cellular proteins that interact with the
COOH-terminal region of p73α and regulate its activity, we employed a yeast-based two …
overexpression of p73 induces cell cycle arrest and/or apoptosis, and these biological
activities are linked to its sequence-specific transactivation function. The COOH-terminal
region of p73 is unique and has a function to modulate DNA-binding ability and
transactivation activity. To identify and characterize cellular proteins that interact with the
COOH-terminal region of p73α and regulate its activity, we employed a yeast-based two …
