[HTML][HTML] A negative feedback control of transforming growth factor-β signaling by glycogen synthase kinase 3-mediated Smad3 linker phosphorylation at Ser-204
C Millet, M Yamashita, M Heller, LR Yu… - Journal of biological …, 2009 - ASBMB
Through the action of its membrane-bound type I receptor, transforming growth factor-β (TGF-
β) elicits a wide range of cellular responses that regulate cell proliferation, differentiation,
and apo pto sis. Many of these signaling responses are mediated by Smad proteins. As
such, controlling Smad activity is crucial for proper signaling by TGF-β and its related factors.
Here, we show that TGF-β induces phos pho ryl a tion at three sites in the Smad3 linker
region in addition to the two C-terminal residues, and glycogen synthase kinase 3 is …
β) elicits a wide range of cellular responses that regulate cell proliferation, differentiation,
and apo pto sis. Many of these signaling responses are mediated by Smad proteins. As
such, controlling Smad activity is crucial for proper signaling by TGF-β and its related factors.
Here, we show that TGF-β induces phos pho ryl a tion at three sites in the Smad3 linker
region in addition to the two C-terminal residues, and glycogen synthase kinase 3 is …
