Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription
J Francis, SK Chakrabarti, JC Garmey… - Journal of Biological …, 2005 - ASBMB
Expression of the insulin gene is nearly exclusive to the β cells of the pancreatic islets.
Although the sequence-specific transcription factors that regulate insulin expression have
been well studied, the interrelationship between these factors, chromatin structure, and
transcriptional elongation by RNA polymerase II (pol II) has remained undefined. In this
regard, recent studies have begun to establish a role for the methylation of histone H3 in the
initiation or elongation of transcription by pol II. To determine a role for the transcriptional …
Although the sequence-specific transcription factors that regulate insulin expression have
been well studied, the interrelationship between these factors, chromatin structure, and
transcriptional elongation by RNA polymerase II (pol II) has remained undefined. In this
regard, recent studies have begun to establish a role for the methylation of histone H3 in the
initiation or elongation of transcription by pol II. To determine a role for the transcriptional …
