Biology of CCR5 and its role in HIV infection and treatment
MM Lederman, A Penn-Nicholson, M Cho, D Mosier - Jama, 2006 - jamanetwork.com
Chemokine receptors are found on cell surfaces and promote cellular migration by
chemotaxis. The CC chemokine receptor 5 (CCR5) is used by the human immunodeficiency
virus (HIV) to infect cells. Strategies that target human CCR5 are therefore being developed
to prevent and treat HIV infection. Antiviral strategies that target a host element necessary for
viral replication may be predicted to interfere with the function of that element and may
therefore adversely affect the host. We conducted a review of the literature between …
chemotaxis. The CC chemokine receptor 5 (CCR5) is used by the human immunodeficiency
virus (HIV) to infect cells. Strategies that target human CCR5 are therefore being developed
to prevent and treat HIV infection. Antiviral strategies that target a host element necessary for
viral replication may be predicted to interfere with the function of that element and may
therefore adversely affect the host. We conducted a review of the literature between …
