[PDF][PDF] Interactions of HIV-1 NEF with cellular signal transducing proteins
GH Renkema, K Saksela - Front Biosci, 2000 - academia.edu
Front Biosci, 2000•academia.edu
Phenotypic effects of Nef expression in cell culture 2.1. Downregulation of CD4 and MHC I
molecules 2.2. Nef increases the infectivity of virus particles 2.3. Nef affects host cell signal
transduction pathways 3. Cellular partners and targets of Nef 3.1. Nef associated SH3
domain-containing proteins 3.1. 1. The PxxP motif of Nef 3.1. 2. Hck and Lyn 3.1. 3. Lck 3.1.
4. More potential Nef-binding SH3 proteins 3.2. Nef associated serine kinases 3.2. 1. p21-
activated kinase-2 3.2. 2. Other Nef-associated serine kinases 3.3. T cell receptor zeta chain …
molecules 2.2. Nef increases the infectivity of virus particles 2.3. Nef affects host cell signal
transduction pathways 3. Cellular partners and targets of Nef 3.1. Nef associated SH3
domain-containing proteins 3.1. 1. The PxxP motif of Nef 3.1. 2. Hck and Lyn 3.1. 3. Lck 3.1.
4. More potential Nef-binding SH3 proteins 3.2. Nef associated serine kinases 3.2. 1. p21-
activated kinase-2 3.2. 2. Other Nef-associated serine kinases 3.3. T cell receptor zeta chain …
Abstract
Phenotypic effects of Nef expression in cell culture 2.1. Downregulation of CD4 and MHC I molecules 2.2. Nef increases the infectivity of virus particles 2.3. Nef affects host cell signal transduction pathways 3. Cellular partners and targets of Nef 3.1. Nef associated SH3 domain-containing proteins 3.1. 1. The PxxP motif of Nef 3.1. 2. Hck and Lyn 3.1. 3. Lck 3.1. 4. More potential Nef-binding SH3 proteins 3.2. Nef associated serine kinases 3.2. 1. p21-activated kinase-2 3.2. 2. Other Nef-associated serine kinases 3.3. T cell receptor zeta chain 3.4. How similar are HIV and SIV Nef proteins? 4. Perspective
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