Effectiveness of live, attenuated intranasal influenza virus vaccine in healthy, working adults: a randomized controlled trial
KL Nichol, PM Mendelman, KP Mallon, LA Jackson… - Jama, 1999 - jamanetwork.com
Context Influenza virus is a major cause of illness, disruption to daily life, and increased use
of health care in all age groups. Objective To assess the safety and effectiveness of
intranasally administered trivalent, live, attenuated influenza virus (LAIV) vaccine for
reducing illness, absenteeism, and health care use among healthy, working adults. Design
Randomized, double-blind, placebo-controlled trial conducted from September 1997
through March 1998. Setting Thirteen centers across the United States. Participants A total of …
of health care in all age groups. Objective To assess the safety and effectiveness of
intranasally administered trivalent, live, attenuated influenza virus (LAIV) vaccine for
reducing illness, absenteeism, and health care use among healthy, working adults. Design
Randomized, double-blind, placebo-controlled trial conducted from September 1997
through March 1998. Setting Thirteen centers across the United States. Participants A total of …
