Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma
M Hoshino, Y Nakamura, QA Hamid - Journal of Allergy and Clinical …, 2001 - Elsevier
Background: Angiogenesis is a feature of airway remodeling in bronchial asthma. The
mechanism responsible for this angiogenesis is unknown. Vascular endothelial growth
factor (VEGF) is a potent inducer of endothelial cells, which may contribute to chronic
inflammation and angiogenesis. Objective: We sought to investigate the molecular
mechanisms underlying increased vascularity, and we examined the mRNA expression of
VEGF and its receptors (flt-1 and flk-1) within bronchial biopsy specimens from asthmatic …
mechanism responsible for this angiogenesis is unknown. Vascular endothelial growth
factor (VEGF) is a potent inducer of endothelial cells, which may contribute to chronic
inflammation and angiogenesis. Objective: We sought to investigate the molecular
mechanisms underlying increased vascularity, and we examined the mRNA expression of
VEGF and its receptors (flt-1 and flk-1) within bronchial biopsy specimens from asthmatic …
