In vitro Suppression of the Lymphocyte Response to Tuberculin by Live Measles Virus.
EM Smithwick, S Berkovich - Proceedings of the Society for …, 1966 - journals.sagepub.com
EM Smithwick, S Berkovich
Proceedings of the Society for Experimental Biology and Medicine, 1966•journals.sagepub.comIn vitro Suppression of the Lymphocyte Response to Tuberculin by Live Measles Virus. Page 1
2 76 MEASLES SUPPRESSION OF LYMPHOCYTE RESPONSE sors which render it refractory
to normal inductive stimuli. On the other hand, the duplicating genome itself may be unable to
simultaneously participate in other functions. The data of these experiments indicate that cells
preparing to divide are less able to respond to an hormonal stimulus than are nondividing
cells. Therefore, the failure or diminution of enzyme induction by steroids in hepatomas is not …
2 76 MEASLES SUPPRESSION OF LYMPHOCYTE RESPONSE sors which render it refractory
to normal inductive stimuli. On the other hand, the duplicating genome itself may be unable to
simultaneously participate in other functions. The data of these experiments indicate that cells
preparing to divide are less able to respond to an hormonal stimulus than are nondividing
cells. Therefore, the failure or diminution of enzyme induction by steroids in hepatomas is not …
Summary
The addition of live measles virus to PPD sensitive lymphocytes has been shown to reduce significantly the mean response of these cells to PPD. The stimulatory effect of PHA in a similar system was not influenced by the measles virus.
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