T cell sensitization to proteolipid protein in myelin basic protein-induced relapsing experimental allergic encephalomyelitis
LL Perry, E Barzaga-Gilbert, JL Trotter - Journal of neuroimmunology, 1991 - Elsevier
Abstract (SJL/J× PL/J) F 1 mice immunized with myelin basic protein (MBP) develop an
autoimmune demyelinating disease termed relapsing experimental allergic
encephalomyelitis (rEAE). The acute stage of disease is mediated by CD4+ T cells specific
for MBP amino acids 1–9. To determine the immunologic bases for disease relapse, host
sensitization to additional autoantigens of the central nervous system was measured.
Results indicate that most animals develop T cell reactivity to endogenous myelin proteolipid …
autoimmune demyelinating disease termed relapsing experimental allergic
encephalomyelitis (rEAE). The acute stage of disease is mediated by CD4+ T cells specific
for MBP amino acids 1–9. To determine the immunologic bases for disease relapse, host
sensitization to additional autoantigens of the central nervous system was measured.
Results indicate that most animals develop T cell reactivity to endogenous myelin proteolipid …
