Glomerular and serum immunoglobulin G subclasses in IgA nephropathy
P Aucouturier, RC Monteiro, LH Noël… - Clinical immunology and …, 1989 - Elsevier
The distribution of human IgG subclasses among mesangial glomerular deposits of 11
patients with IgA nephropathy (IgA-N) was examined by indirect immunofluorescence with
subclass-specific mouse monoclonal antibodies (mAb). A subclass restriction was observed
with mesangial deposits containing almost exclusively IgG1 (81% of the studied biopsies)
and IgG3 (64%). IgG2 was present in only 1 out of the 11 cases studied and IgG4 was never
found to be present, although seven different anti-IgG4 mAb were used. In addition, serum …
patients with IgA nephropathy (IgA-N) was examined by indirect immunofluorescence with
subclass-specific mouse monoclonal antibodies (mAb). A subclass restriction was observed
with mesangial deposits containing almost exclusively IgG1 (81% of the studied biopsies)
and IgG3 (64%). IgG2 was present in only 1 out of the 11 cases studied and IgG4 was never
found to be present, although seven different anti-IgG4 mAb were used. In addition, serum …
