Abnormalities in cell-cell communication and growth factor signaling pathways can
lead to defects in maternal-fetal interactions during pregnancy, including
immunologic rejection of the fetal/placental unit. In this study, we discovered that
bone morphogenetic protein receptor type 2 (BMPR2) is essential for postimplantation
physiology and fertility. Despite normal implantation and early placental/fetal
development, deletion of
Takashi Nagashima, Qinglei Li, Caterina Clementi, John P. Lydon, Francesco J. DeMayo, Martin M. Matzuk
Increased trophoblast giant cells, regressed formation of ectoplacental cone,
and failure of fetal blood vessel formation in implantation sites of